Barangay Sta. Cruz is a barangay located in Makati's first congressional district. It is bounded by Barangay Olympia in the north, Manila South Cemetery of the City of Manila to the east, Barangays Bel-Air and San Antonio to the south, and Barangays La Paz and Tejeros to the west. The Barangay is a member of the Northwest Cluster, or Cluster 3 of Makati.
Barangay Sta. Cruz hosts one of the known public cemeteries in Metro Manila, which is the Manila South Cemetery. It covers 0.91% of the barangay, while 0.36% is used as residential area. Sta. Cruz’s population as of 2010 is 7,440, which is 1.40% of the total population of Makati City. On the other hand, the barangay’s land area is 0.473 square kilometers or 1.70% of the total land area of Makati. There are 16 residents per 1,000 square meters.