Barangay San Antonio is one of the seven (7) barangays comprising the Westside Cluster or Cluster 2. It has a land area of 0.8958 square kilometers which occupies 3.3% of the City’s total land area. Based on the 2010 census of population released by the National Statistics Office, San Antonio has a percentage share of 2.2% or 11,443 versus the City’s population with a density of 13 persons per 1,000 square meters.
San Antonio is bounded Barangay La Paz in the north, Barangays Pio Del Pilar and San Lorenzo in the south, Barangays Sta. Cruz and Bel-Air in the east, and Barangay Palanan in the west.
Barangay San Antonio once housed the Makati Polytechnic University or Pamantasan ng Makati before it was relocated to Brgy. West Rembo and converted to now University of Makati. Other recognized structures located in the barangay include the San Antonio National High School, San Antonio Elementary School, National Shrine of the Sacred Heart, and St. Paul the Apostle Sanctuary and ST. PAULS - an international Catholic religious congregation composed of priests and brothers. Moreover, the most notable personality residing in Barangay San Antonio is Vice President Jejomar C. Binay and his family.
Predominant land use of Barangay San Antonio is commercial and can be seen through the wide array of business establishments ranging from banks, restaurants, shipping companies, wine/liquor stores, recruitment agencies and condominiums/apartelles among others.