Guadalupe Nuevo is part of the North Central Cluster along with Pitogo, Pinagkaisahan, Post Proper Southside, and South Cembo. Being situated at the north central cluster, part of Guadalupe Nuevo lying along EDSA and Kalayaan Avenue are generally classified as commercial areas while inner portions are mostly residential.
Predominantly, the type of business establishments located within the barangay are small and medium stores, banks, restaurants, hotels/tourism-related establishments, among others. Also, the largest public wet market of Makati is located at the barangay.
Based on the 2010 Census of Population conducted by the National Statistics Office, Guadalupe Nuevo has a percentage share of 3.5% or 18,271 population count versus the city’s population, with an estimate of at least 3,655 households. By population density, on the other hand, considering its land area and population count, the barangay has 32 residents per 1,000 square meters.